Spatiotemporal Plasticity Of Mirnas Functions: The Mir-17-92 Case
MOLECULAR & CELLULAR ONCOLOGY（2016）
摘要
The functional effect of a specific miRNA is tightly linked to the transcriptome, thus having the potential to elicit distinct outcomes in different cellular states. Our recent discovery of a dual role of the miR-17-92 cluster, which shifts from oncogene to tumor suppressor during lymphoma progression, exemplifies the spatiotemporal plasticity of miRNAs.
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关键词
Alternative polyadenylation (APA), miRNA, miR-17-92, 3 '-UTR shortening
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