Screening and characterization of molecules that modulate the biological activity of IFNs-I.

Milagros Bürgi,Viktor A Zapol'skii,Bettina Hinkelmann,Mario Köster,Dieter E Kaufmann,Florenz Sasse,Hansjörg Hauser,Marina Etcheverrigaray,Ricardo Kratje,Mariela Bollati-Fogolín,Marcos Oggero

Journal of Biotechnology（2016）

引用 8|浏览13

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摘要

•A low throughput assay to identify modulators of interferons activity is described.•The assay was adapted to a range of cell-lines covering several cellular environments.•Two collections of 154 natural and 288 synthetic compounds respectively were tested.•One enhancer and 5 inhibitors of interferon activity were identified.

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关键词

APA,AVA,C+,C-,CC,CWT,DMSO,EGFP,EnE,FCS,FSC,GepA,hIFNs-I,HTS,IFNs,IFNs-I,IFN+C,IRF7,ISG,ISRE,LC–MS,LTS,mCHR,NSE,PBS,Pella,PI,RCLs,RGAs,rhIFN,RsE,RvE,SCC,Sula,TubI,VioB,VSV,σpos,σneg,μpos,μneg

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