ECM-mimetic heparin glycosamioglycan-functionalized surface favors constructing functional vascular smooth muscle tissue in vitro.

Jimin Zhang,Jianing Wang,Yongzhen Wei,Cheng Gao,Xuejiao Chen,Wei Kong,Deling Kong,Qiang Zhao

Colloids and Surfaces B: Biointerfaces（2016）

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摘要

⿢Heparin-functionalized PCL surface was prepared by a facile and efficient method.⿢It allows the regulation of growth and phenotype of vascular smooth muscle cells.⿢A confluent layer of contractile smooth muscle has been successfully generated.

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关键词

PCL electrospun scaffold,Heparin,Surface functionalization,Vascular smooth muscle cells (VSMCs),Phenotype regulation

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