Pharmacokinetics and pharmacodynamics of sulfamethoxazole and trimethoprim in swimming crabs (Portunus trituberculatus) and in vitro antibacterial activity against Vibrio: PK/PD of SMZ-TMP in crabs and antibacterial activity against Vibrio.

•The antibacterial activity against Vibrios showed the in vitro activity during various SMZ-TMP ratios.•The pharmacokinetics of SMZ-TMP were explored the pharmacokinetic properties of SMZ-TMP combination in tissue of crabs.•We recommend SMZ-TMP combination in ratio of 1:1 was used to cure the bacterial disease in crabs.