Denosumab could be a Potential Inhibitor of Valvular Interstitial Cells Calcification in vitro .

Daniel Alejandro Lerman,Sai Prasad,Nasri Alotti

International journal of cardiovascular research（2016）

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摘要

This study has proved that Denosumab could be a potential inhibitor of the calcification of VICs . A fuller understanding of the actions of Denosumab may identify a novel therapeutic strategy for clinical intervention against aortic valve calcification and aortic stenosis.

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关键词

Aortic valve calcification disease,Aortic valve interstitial cells,Calcification,Denosumab,Porcine VICs model,RANK,RANKL

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