Bile acid receptor agonists INT747 and INT777 decrease oestrogen deficiency-related postmenopausal obesity and hepatic steatosis in mice.

Monique C de Oliveira,Eduardo H Gilglioni,Bouke A de Boer,Jurgen H Runge,Dirk R de Waart,Clairce L Salgueiro,Emy L Ishii-Iwamoto,Ronald P J Oude Elferink,Ingrid C Gaemers

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease（2016）

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摘要

Menopause is often followed by obesity and, related to this, non-alcoholic fatty liver disease (NAFLD). Two bile acid (BA) receptors, farnesoid X receptor (FXR) and G-protein-coupled receptor TGR5, have emerged as putative therapeutic targets for obesity and NAFLD.

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关键词

NAFLD,BA,FXR,TGR5,OVX,HFD,MRI,TG,ERT,6-ECDCA,GPCRs,Dio 2,S-EMCA,BW,PUAT,PBS,BAT,VO2,VCO2,EE,HE,Chol,BCA,qPCR,Acox1,Cpt1,Pck,G6pc,WAT,c/Ebpα,PPARγ,Ucp1,PGC1α,Sirt1,Shp,Pltp1,UCP3,Pdk4,Fasn,Fgf21,Ces-1,Fsp27

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