Group III mGluR8 negatively modulates TRPA1.

Neuroscience（2016）

引用 4|浏览9

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摘要

•TRPA1 activation induces mechanical sensitivity in vivo and in vitro.•TRPA1 and mGluR8 are co-localized.•mGluR8 activation attenuates TRPA1-induced activity in vivo and in vitro.•mGluR8 negatively modulates TRPA1 activity through the cAMP/PKA pathway.

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关键词

AC,cAMP,DCPG,DRG,ES,FSK,mGluR,MO,NMDA,PBS,PKA,PKC,PWT,RpCAMPS,SCG,TRPA1,TRPV1,UBP

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