A strategy of designing the ligand of antibody affinity chromatography based on molecular dynamics simulation

Lu Dai,Weikang Li,Fei Sun,Baizhi Li,Hongrui Li,Hongxing Zhang,Qingchuan Zheng,Chongyang Liang

Journal of Chromatography A（2016）

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摘要

•A new strategy to design ligand of antibody affinity media by MD simulation.•Bioinformatics, Genetic Engineering and SPR test form the new strategy.•A tetramer of SpA domain D mutant exerted higher binding ability in SPR test.

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关键词

Molecular dynamics,Staphylococcal protein A,Ligand,Surface plasmon resonance

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