L-type calcium channel antagonism - Translation from in vitro to in vivo.

Bernard Fermini,David S Ramirez,Sunny Sun,Asser Bassyouni,Michelle Hemkens,Todd Wisialowski,Stephen Jenkinson

Journal of Pharmacological and Toxicological Methods（2017）

引用 9|浏览10

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摘要

These results suggest that in vitro and ex vivo profiling remains a valuable tool in predicting potential in vivo cardiovascular safety issues, and can aid in the selection of novel development compounds that show inherent inhibitory activity against L-type calcium channels.

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关键词

Calcium channel,L-type,Nifedipine,Verapamil,Diltiazem,Aorta,Langendorff,In vivo,In vitro,Rat telemetry

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