Chemical screening identifies ATM as a target for alleviating senescence

Hyun Tae Kang,Joon Tae Park, Kobong Choi, Yongsub Kim,Hyo Jei Claudia Choi,Chul Won Jung,Young-Sam Lee,Sang Chul Park

NATURE CHEMICAL BIOLOGY（2017）

引用 122|浏览8

暂无评分

摘要

xia telangiectasia mutated (ATM) directly interacts with and phosphorylates the V-ATPase V 1 subunit ATP6V1G1, thereby decreasing V 1 -V 0 assembly in the V-ATPase. Attenuation of ATM activity results in lysosomal pH acidification, recovery of autophagy and alleviation of senescence.

查看译文

关键词

Kinases,Post-translational modifications,Small molecules,Chemistry/Food Science,general,Biochemical Engineering,Biochemistry,Cell Biology,Bioorganic Chemistry

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要