Tetraspanin 1 Promotes Epithelial-to-mesenchymal Transition and Metastasis of Cholangiocarcinoma Via PI3K/AKT Signaling.

Journal of experimental & clinical cancer research（2018）

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摘要

Numerous studies have demonstrated that tetraspanin 1 (TSPAN1), a transmembrane protein, functions as an oncoprotein in many cancer types. However, its role and underlying molecular mechanism in cholangiocarcinoma (CCA) progression remain unclear.

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关键词

Cholangiocarcinoma,Tetraspanin 1,Epithelial-to-mesenchymal transition,MicroRNA-194-5p,Integrin α6β1

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