Stitching Up Broken Dna Ends By Fanca

Anna Palovcak,Wenjun Liu,Fenghua Yuan,Yanbin Zhang

MOLECULAR & CELLULAR ONCOLOGY（2018）

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摘要

RAD52 rejoins resected broken DNA ends by mediating single-strand annealing. Our recent work elucidates that FANCA, a Fanconi anemia protein, also directly repairs double-strand breaks (DSBs) by catalyzing annealing of single-stranded DNA. FANCA and RAD52 likely play complementary roles to each other to prevent deleterious consequences of DSBs.

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关键词

FANCA, Fanconi anemia, double strand break repair, interstrand crosslink repair

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