Aspirin pre-treatment modulates ozone-induced fetal growth restriction and alterations in uterine blood flow in rats

Colette N. Miller,Urmila P. Kodavanti,Erica J. Stewart, Mette Schaldweiler,Judy H. Richards,Allen D. Ledbetter, Leslie T. Jarrell,Samantha J. Snow,Andres R. Henriquez,Aimen K. Farraj,Janice A. Dye

Reproductive Toxicology（2019）

引用 6|浏览12

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摘要

•Peri-implantation ozone exposure impairs uterine arterial blood flow and reduces fetal growth.•Low dose aspirin given during early pregnancy improves fetal weight.•Continued aspirin treatment does not protect against fetal growth restriction.•Aspirin treatment throughout the entirety of pregnancy induces placental inefficiency.

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关键词

Aspirin,Ozone,Intrauterine growth restriction,Uterine arterial flow,Placenta,Antioxidants

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