Association of Endothelin-1 with Accelerated Cardiac Allograft Vasculopathy and Late Mortality Following Heart Transplantation.

•An ET-1 level >1.75 pg/mL soon after HT independently predicts accelerated CAV.•ET-1 appears to primarily contribute to disease progression via negative remodeling.•Baseline ET-1 >1.75 pg/mL is also an independent predictor of late mortality.•These data imply that ET-1 may have durable prognostic value for HT populations.