An early feasibility study of the Nativis Voyager® device in patients with recurrent glioblastoma: first cohort in US.
CNS oncology(2018)
摘要
AIM:Evaluation of the Nativis Voyager® device in patients with recurrent glioblastoma (rGBM).
MATERIALS & METHODS:Voyager is a noninvasive, nonthermal, nonionizing and portable investigational device which delivers ultra-low radio frequency energy (ulRFE®) that uses a magnetic field to penetrate tissues to alter specific biologic functions within cells. Patients with rGBM were treated with Voyager alone (V) or Voyager in combination with standard of care (V + SoC). Safety and clinical utility were assessed every 2-4 months.
RESULTS:Data from the first 11 patients treated are reported here. Median progression-free survival was 10 weeks in the V arm and 16 weeks in the V + SoC arm. Median overall survival was 16 months in V arm and 11 months in the V + SoC arm. No serious adverse events associated with the device were reported.
CONCLUSION:These data suggest that the Voyager is safe and feasible for the treatment of rGBM.
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关键词
clinical trials,medical device,novel therapy,recurrent GBM,ultra-low radiofrequency energy, brain tumor
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