Therapeutic Effect of Ultrasound Interventional Perirenal Catheter-Assisted Early Peripancreatic Lavage of Protease Inhibitor on Severe Acute Pancreatitis in Miniature Pigs

Objectives: To study the therapeutic effect of early peripancreatic lavage of ulinastatin on severe acute pancreatitis(SAP). Methods: Sixteen pigs were divided into 4 groups: model(SAP), saline lavage(SL), ulinastatin lavage(UL), intravenous ulinastatin(IU). UL and SL group were given peripancreatic lavage of ulinastatin by ultrasound-guided perirenal catheterization and IU group was intravenously instilled with ulinastatin. The multi-organ functions and the inflammatory factors were observed. Results: UL group has the best therapeutic effect. The changes of multi-organ functions and the inflammatory factors were compared with SAP group as follows. In time window of treatment: amylase (p < 0.01), lipase (p < 0.01), ALT (p > 0.05), AST (p < 0.05), CR (p < 0.01), UR (p < 0.01), IL-6 (p < 0.01), IL-10 (p < 0.01). In post-treatment phase: amylase (p < 0.01), lipase (p < 0.01), ALT (p < 0.01), AST (p < 0.01), CR (p <0.05), UR (p > 0.05), IL-6 (p <0.01), IL-10 (p <0.01). Conclusions: Early peripancreatic lavage of ulinastatin in SAP could effectively improve the multi-organ functions and inflammatory response. (C) 2018 IAP and EPC. Published by Elsevier B.V.