Low molecule weight fucoidan mitigates atherosclerosis in ApoE (-/-) mouse model through activating multiple signal pathway.

•Low molecule weight fucoidan ameliorates the biochemical indices and atherosclerotic lesions in atherosclerotic mice.•Low molecule weight fucoidan has significant antioxidant and anticoagulant activities.•Low molecule weight fucoidan inhibits smooth muscle cell proliferation and migration and macrophage differentiation.•Low molecule weight fucoidan mitigates atherosclerosis through activating multiple signal pathway.