Compound Genomic Alterations of TP53, PTEN, and RB1 Tumor Suppressors in Localized and Metastatic Prostate Cancer.

Anis A Hamid,Kathryn P Gray,Grace Shaw,Laura E MacConaill,Carolyn Evan,Brandon Bernard,Massimo Loda,Niall M Corcoran,Eliezer M Van Allen,Atish D Choudhury,Christopher J Sweeney

European Urology（2019）

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摘要

Alterations of TP53, PTEN, and RB1 tumor suppressor genes are present across the clinical spectrum of prostate cancer and are particularly frequent in metastatic and castration-resistant disease. Alterations are associated with poorer outcomes, with incremental risk seen with compound loss, thereby identifying at-risk patient subgroups in the early and advanced disease settings.

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关键词

Prostate cancer,PTEN,TP53,p53,RB1,Rb,Tumor suppressor genes,Next-generation sequencing,Genomics,Precision medicine

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