T-Cell Large Granular Lymphocyte Leukemia Transfomation Into Aggressive T-Cell Lymphoma: A Report Of Two Cases With Molecular Characterization

Maya Belhadj, Dalila Mansour,Sophie Kaltenbach, Benedicte Deau-Fischer,Patricia Franchi, Jerome Tamburini,Nicolas Chapuis, Diane Damotte,Olivier Kosmider, Barbara Burroni,Didier Bouscary

HAEMATOLOGICA（2019）

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摘要

T-cell large granular lymphocyte (LGL) leukemia, a clonal expansion of cytotoxic CD3+ T cells, represents 5% of lymphoproliferative disorders. Clinical features include neutropenia causing recurrent bacterial infections, anemia of diverse mechanisms, and autoimmune diseases such as rheumatoid

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关键词

Aggressive Non-Hodgkin's Lymphoma,Cytogenetics and Molecular Genetics,Lymphoproliferative Disorders

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