Potential biomarker for breast cancer screening: A systematic review and meta-analysis.

Abstract It is aimed of evaluating the clinical significance of miR-155 on diagnosing human breast cancer. Method: Eligible studies were identified through multiple search strategies. The search was updated up until April 10, 2017. Fagan’s nomogram, Publication bias, meta-regression, sensitive analysis, area under the summary receiver operating characteristic (AUC), diagnostic odds ratio (DOR) as well as pooled sensitivity and specificity were utilized to assess the capacity of miR-155 for diagnosis. The meta-analysis was conducted and the origin of heterogenic property was investigated by Stata SE 12.0 and Meta-Disc software. Results: The meta-analysis contained nine articles totally with the AUC, DOR, specificity, pooled sensitivity of 36.45 (95 % CI 9.77–136.04), 0.92 (95 % CI 0.89–0.94), 0.82 (95 % CI 0.67–0.91) and 0.89 (95 % CI 0.77–0.95) separately. The negative and positive likelihood ratios were 0.14 and 5. Moreover, the heterogeneity was obviously apparent but resulted from neither sensitivity analyses nor threshold effect. Conclusion: The evidence from this study indicates that miR-155 exhibits satisfactory performance on diagnosis for breast cancer (BC).