Design, Synthesis and Biological Activity of Novel Substituted Diamides Derivatives Containing Thiophene Ring

To discover novel diamide derivatives with high insecticidal activity, a series of new substituted diamide derivatives (1-3) containing thiophene ring was synthesized by introducing thiophene ring to diamide derivatives utilizing intermediate derivatization methods (IDM). The compounds were identified by H-1 NMR, IR and elemental analysis. Preliminary bioassays indicated that compound 1 exhibited excellent insecticidal activities against Plutella xylostella and showed 100% mortality at 600 mg/L. Compounds la and le showed above 60% mortality at 20 mg/L. Compounds 2 and 3 attained by changing the pyrazole ring in diamide derivatives have no insecticidal activity, which illustrated that, pyrazole ring in diamide derivatives is very important.