The long noncoding RNA LncHDAC2 drives the self-renewal of liver cancer stem cells via activation of Hedgehog Signaling.

Jiayi Wu,Pingping Zhu,Tiankun Lu,Ying Du, Yanying Wang,Luyun He,Buqing Ye,Benyu Liu,Liuliu Yang,Jing Wang,Yang Gu,Jie Lan,Yajing Hao,Lei He,Zusen Fan

Journal of Hepatology（2019）

引用 94|浏览67

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摘要

•Long non-coding RNA lncHDAC2 is highly expressed in liver cancer stem cells.•LncHDAC2 promotes the self-renewal of liver cancer stem cells.•LncHDAC2 associates with HDAC2 in liver cancer stem cells.•LncHDAC2-mediated PTCH1 downregulation promotes Hh signaling, driving self-renewal of liver cancer stem cells.

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关键词

Hepatocellular carcinoma,Cancer stem cell,lncHDAC2,HDAC2,PTCH1

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