Resolution of Inflammation Through the Lipoxin and ALX/FPR2 Receptor Pathway Protects Against Abdominal Aortic Aneurysms.

Marcelo H Petri,Silke Thul,Teodora Andonova,Moritz Lindquist-Liljeqvist,Hong Jin,Nikolaos-Taxiarchis Skenteris,Hildur Arnardottir,Lars Maegdefessel,Kenneth Caidahl,Mauro Perretti,Joy Roy,Magnus Bäck

JACC: Basic to Translational Science（2018）

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摘要

•Specialized lipid mediators transduce the resolution of inflammation by means of the ALX/FPR2.•Human AAA exhibited decreased ALX/FPR2 expression.•Genetic disruption of the murine ALX/FPR2 ortholog exacerbated AAA and increased inflammation.•The ALX/FPR2 agonist ATL induced pro-resolving signaling in bone marrow-derived murine cells.•Pro-resolving signaling by means of the ALX/FPR2 receptor may decrease the progression of AAA.

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关键词

abdominal aortic aneurysms,cardiovascular disease,eicosanoids,inflammation,lipoxygenase

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