An Automated Multidose Synthesis of the Potentiometric PET Probe 4-[18F]Fluorobenzyl-Triphenylphosphonium ([18F]FBnTP)

Christopher M. Waldmann,Adrian Gomez,Phillip Marchis,Sean T. Bailey,Milica Momcilovic,Anthony E. Jones,David B. Shackelford,Saman Sadeghi

MOLECULAR IMAGING AND BIOLOGY（2018）

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摘要

The aim of this study was the automated synthesis of the mitochondrial membrane potential sensor 4-[18F]fluorobenzyl-triphenylphosphonium ([18F]FBnTP) on a commercially available synthesizer in activity yields (AY) that allow for imaging of multiple patients.

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关键词

4-[18F]Fluorobenzyl-triphenylphosphonium,[18F]FBnTP,Mitochondrial metabolism,Positron emission tomography,4-[18F]fluorobenzaldehyde,Radiolysis,Antioxidants,Solid-phase extraction purification

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