Effect of adoptive transfer of CD4 + CD25 + Foxp3 + Treg induced by trichostatin A on the prevention of spontaneous abortion.

Jian Wang,Jing Yang,Yuqing Yan,Zhuangyan Zhu,Yaqin Mu,Xiying Wang,Jinhua Zhang,Lihua Liu,Fuxi Zhao,Yuling Chi

Journal of Reproductive Immunology（2019）

引用 26|浏览4

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摘要

•TSA was applied to the epigenetic modification of the special location of Foxp3 gene in CD4+CD25− T cells of miscarried mice.•Adoptive transfer of CD4+CD25+Foxp3+iTregs can reduce the abortion rate.•Transfusion with iTregs at early stage of pregnancy is more effective.

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关键词

Unexplained recurrent spontaneous abortion,Histone modification,Trichostatin A,CD4+CD25+Foxp3+ Treg,Adoptive transfer,Embryo resorption rate

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