Link-A Incrna A Promotes Proliferation And Inhibits Apoptosis Of Mantle Cell Lymphoma Cell By Upregulating Survivin

Background: LINK-A IncRNA acts as an oncogene in triple-negative breast cancer, but its involvement in other diseases is unknown. The present study was performed to investigate the involvement of LINK-A IncRNA in mantle cell lymphoma.Material/Methods: Expressions of LINK-A IncRNA and survivin in plasma of patients with mantle cell lymphoma and healthy controls were detected by qRT-PCR and ELISA, respectively. ROC curve analysis was performed to investigate the diagnostic value of LINK-A IncRNA for mantle cell lymphoma. Correlations between plasma level of LINK-A IncRNA and survivin were analyzed by Pearson correlation coefficient. LINK-A IncRNA shRNA and expression vector were transfected into cells of human mantle cell lymphoma cell lines, followed by detection of cell proliferation, cell apoptosis, and survivin expression by cell proliferation assay, cell apoptosis assay, and Western blot analysis, respectively.Results: We found that, compared with healthy controls, plasma levels of LINK-A IncRNA and survivin were significantly increased in patients with mantle cell lymphoma. Upregulation of LINK-A IncRNA sensitively distinguished patients with mantle cell lymphoma from healthy controls. Plasma levels of LINK-A IncRNA and survivin were positively correlated in mantle cell lymphoma patients but not in healthy controls.Conclusions: LINK-A IncRNA overexpression promoted cell proliferation, inhibited cell apoptosis, and upregulated survivin expression, while LINK-A IncRNA knockdown had the opposite effect.