Porcine reproductive and respiratory syndrome virus counteracts type I interferon-induced early antiviral state by interfering IRF7 activity.

Ke Liu,Gaini Ma,Xiqian Liu,Yan Lu,Shumin Xi,Anni Ou,Jianchao Wei,Beibei Li,Donghua Shao,Yuming Li,Yafeng Qiu,Denian Miao,Zhiyong Ma

Veterinary Microbiology（2019）

引用 11|浏览20

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摘要

•Type I interferon induces antiviral response to inhibit PRRSV early replication.•IRF7 transcription and expression are counteracted by PRRSV infection.•PRRSV nsp7 impair IRF7 transcription and expression.

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关键词

Porcine reproductive and respiratory syndrome virus,RNA-Seq,IRF7,Non-structure protein 7

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