Incomplete Suppression of HIV-1 by SAMHD1 Permits Efficient Macrophage Infection.

Timothy Plitnik,Mark E Sharkey,Bijan Mahboubi,Baek Kim,Mario Stevenson

Pathogens & immunity（2018）

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摘要

Our study reveals fundamental differences between HIV-1 and SIV in the strategy used to evade restriction by SAMHD1 and suggests a degree of resistance of HIV-1 to the antiviral environment created by SAMHD1. Understanding how these cellular restrictions antagonize viral replication will be important for the design of novel antiviral strategies.

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HIV-1,SAMHD1,macrophages

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