Chemogenetic Targeting of Dorsomedial Direct-Pathway Striatal Projection Neurons Selectively Elicits Rotational Behavior in Mice.

Andreas Bay Kønig, Chiara Ciriachi,Ulrik Gether,Mattias Rickhag

Neuroscience（2019）

引用 14|浏览19

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摘要

•Chemogenetic inhibition of dorsomedial dSPNs selectively elicits ipsiversive rotations.•Chemogenetic inhibition of dorsomedial dSPNs shows no effect on general locomotion.•A positive linear correlation was found between turn ratio and area of viral expression.•Rotational behavior is a sensitive measure of dSPN performance.

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关键词

6-OHDA,AAALAC,AAV,AB,ANOVA,AP,BAC,bp,BSA,cAMP,CL,CNO,CSF,DAT,DMSO,DNA,dNTPs,DREADD,dSPN,DV,EDTA,GABA,GENSAT,GIRK,GPCR,GPe,GPi,hM4Di,i.p.,IL,ir,iSPN,ML,PBS,PCR,PFA,PKA,ROI,SEM,SNc,SNr,SPN,STN,TH,VTA,WT

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