Peripheral nervous system effects in the PS19 tau transgenic mouse model of tauopathy.

Jesús Merchán-Rubira,Álvaro Sebastián-Serrano,Miguel Díaz-Hernández,Jesús Avila,Félix Hernández

Neuroscience Letters（2019）

引用 10|浏览7

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摘要

•PS19 mice with P301S tau suffer progressive motor degeneration and premature death.•P301S tau is expressed in sciatic nerves (western blot and immunohistochemistry).•Electron microscopy of sciatic nerve showed myelin alterations: lamellae detachment.•Sciatic nerves should be analyzed regarding motor performance and survival of PS19.

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关键词

Sciatic nerve,Neurodegeneration,Tauopathies

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