Loss of nuclear REST/NRSF in aged-dopaminergic neurons in Parkinson's disease patients.

Miwako Kawamura,Shigeto Sato,Gen Matsumoto,Takahiro Fukuda,Kahori Shiba-Fukushima,Sachiko Noda,Masashi Takanashi,Nozomu Mori,Nobutaka Hattori

Neuroscience Letters（2019）

引用 33|浏览14

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摘要

•Nuclear accumulation of REST occurs as a normal aging process.•Lewy pathology disturbs the nuclear accumulation process in dopaminergic neurons by sequestering REST.•The loss of nuclear REST in aged-dopaminergic neurons may associate with the Parkinson’s disease pathogenesis.

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关键词

Parkinson’s disease,Dementia with Lewy bodies,REST,NRSF,Lewy body

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