Pseudogene Repair Driven by Selection Pressure Applied in Experimental Evolution
Nature microbiology(2019)
摘要
Pseudogenes represent open reading frames that have been damaged by mutations, rendering the gene product non-functional. Pseudogenes are found in many genomes and are not always eliminated, even if they are potentially ‘wasteful’. This raises a fundamental question about their prevalence. Here we report pseudogene efeU repair that restores the iron uptake system of Escherichia coli under a designed selection pressure during adaptive laboratory evolution.
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关键词
Bacterial evolution,Bacterial physiology,Evolution,Experimental evolution,Genetics,Life Sciences,general,Microbiology,Medical Microbiology,Parasitology,Infectious Diseases,Virology
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