Emergence of membrane sphingolipids as a potential therapeutic target.

•Sphingolipids, an integral part of eukaryotic membranes, have indispensable functions in myriad of cellular events.•There is a whopping 28-fold increase in the sphingolipid-based research over the past two decades.•Sphingolipids are emerging as a goldmine for new therapeutic drug targets.•Targeting the enzymes involved in sphingolipid pathway, and their plausible “druggability” is highly promising.