Repression of lncRNA NEAT1 enhances the antitumor activity of CD8 + T cells against hepatocellular carcinoma via regulating miR-155/Tim-3.

Kai Yan,Yong Fu,Nan Zhu,Zhuo Wang, Jin-Ling Hong,Yao Li,Wei-Jing Li,Hai-Bin Zhang,Jing-Hai Song

The International Journal of Biochemistry & Cell Biology（2019）

引用 83|浏览15

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摘要

Via modulating the miR-155/Tim-3 pathway, repression of NEAT1 restrained CD8T cell apoptosis and enhanced the cytolysis activity against HCC, implying an effective target for improving the outcome of immunotherapy.

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关键词

Hepatocellular carcinoma,NEAT1,miR-155,Tim-3,CD8+T cells

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