Development of a highly sensitive liquid chromatography with tandem mass spectrometry method for the qualitative and quantitative analysis of high-intensity sweeteners in processed foods.

Keiko Iwakoshi,Shoichi Tahara,Yoko Uematsu,Yukiko Yamajima,Hiroyuki Miyakawa,Kimio Monma,Chigusa Kobayashi,Ichiro Takano

Journal of Chromatography A（2019）

引用 14|浏览5

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摘要

•A method can determine advantame (Ad) and neotame (Neo) in processed foods.•Analyte separation was accomplished for only 10 min.•The method involved rapid dialysis without a clean-up step using SPE.•This method was validated using five food products.•This method allowed the Ad and Neo content using the developed MRM-IDA-EPI method.

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关键词

Advantame,Neotame,Sweetener,Liquid chromatography (LC),Tandem mass spectrometry (MS/MS),Charge-surface-modified C18,External solvent-calibration curve,Processed foods,MRM,IDA,Food,Dialysis,Japanese market

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