Long-term local PDGF delivery using porous microspheres modified with heparin for tendon healing of rotator cuff tendinitis in a rabbit model.

Seok Kang,Joon Shik Yoon,Jae Yong Lee,Hak-Jun Kim,Kyeongsoon Park,Sung Eun Kim

Carbohydrate Polymers（2019）

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摘要

•PDGF/Hep-PMSs were prepared to treat the rotator cuff (RC) tendinitis.•PDGF/Hep-PMSs decreased the levels of pro-inflammatory cytokines in inflamed tenocytes.•PDGF/Hep-PMSs are effective in suppressing in vivo inflammation of RC tendinitis.•PDGF/Hep-PMSs have also a great potential for enhancing tendon healing of RC tendinitis.

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关键词

Poly (lactic-co-glycolic acid) (PLGA) (Pubchem CID: 23111554),Polyvinyl alcohol (PVA) (PubChem CID: 11199),Dichloromethane (DCM) (PubChem CID: 6344),Dimethylsulfoxide (DMSO) (PubChem CID: 679),Recombinant human PDGF (PubChem SID: 135290697),Dopamine hydrochloride (PubChem CID:65340),Thiazolyl blue tetrazolium bromide (MTT) (PubChem CID:64965),Heparin sodium (PubChem CID:22833565),2-(N-morpholino)-ethanesulfonic acid (Pubchem CID:4478249),Sodium chloride (PubChem CID:5234)

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