Polychlorinated biphenyl quinone-induced signaling transition from autophagy to apoptosis is regulated by HMGB1 and p53 in human hepatoma HepG2 cells.

Qiong Shi,Yawen Wang,Wenjing Dong,Erqun Song,Yang Song

Toxicology Letters（2019）

引用 11|浏览3

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摘要

•PCB quinone metabolite elicited both autophagy and apoptosis.•Relocation of ATG5 and Beclin1 suggested autophagy-to-apoptosis signaling.•HMGB1 and p53 regulate PCB quinone-induced autophagy and apoptosis.

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关键词

ATG5,Bak,Bax,Bcl-2,Cyt c,DRAM,HMGB1,HSPB1,LC3B,MMP,PCBs,PI3K,RAGE,TUNEL,ULK1

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