Activation of the calcium-sensing receptor in human valvular interstitial cells promotes calcification.

Hawraa Issa,Lucie Hénaut, Jeanne Bou Abdallah,Cédric Boudot,Gaëlle Lenglet,Carine Avondo,Aida Ibrik,Thierry Caus,Michel Brazier,Romuald Mentaverri,Kazem Zibara,Saïd Kamel

Journal of Molecular and Cellular Cardiology（2019）

引用 9|浏览15

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摘要

•Human valvular interstitial cells (hVICs) express the calcium-sensing receptor (CaSR)•CaSR activation promoted the mineralization and osteogenic transition of hVICs.•CaSR activation reduced the expression of the calcification inhibitor osteopontin.•In hVICs, the CaSR might be a key promoter of calcific aortic valve disease progression

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关键词

Calcium-sensing receptor,Cardiac valve calcification,Valvular interstitial cell

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