Ontogeny of ADME Processes during Postnatal Development in Man and Preclinical Species: A Comprehensive Review.

Luc M De Schaepdrijver,Pieter P J Annaert, Connie L Chen

Drug metabolism and disposition: the biological fate of chemicals（2019）

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摘要

Substantial differences can exist in the absorption, distribution, metabolism, and excretion (ADME) of orally and/or systemically administered medicines depending on the age of patients or animals, leading to potential differences in drug efficacy and toxicity. These differences are usually most

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