Liraglutide prevents β-cell apoptosis via inactivation of NOX2 and its related signaling pathway.

Min Ding,Qian-Hua Fang,Yuan-Tao Cui,Qi-Ling Shen,Qian Liu,Peng-Hua Wang,De-Min Yu,Chun-Jun Li

Journal of Diabetes and its Complications（2019）

引用 27|浏览11

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摘要

The p-AMPKα/NOX2/JNK1/2 pathway is essential for liraglutide to attenuate HG-induced β-cell apoptosis, which further proves that GLP-1Ras may become promising therapeutics for diabetes mellitus.

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关键词

Apoptosis,Liraglutide,GLP-1,NOX2,β-Cells

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