Vascular endothelial Cdc42 deficiency delays skin wound-healing processes by increasing IL-1β and TNF-α expression.
American journal of translational research(2019)
摘要
Angiogenesis is an important step in skin wound repair. Angiogenesis is affected by the functions of many types of cells, especially endothelial cells. Cdc42 plays a vital role in endothelial cell function and vascular development; however, the role of Cdc42 in skin microvascular permeability and skin wound healing is unclear. This study investigated the involvement of Cdc42 in skin wound-healing processes based on its known roles in angiogenesis. Full-thickness skin wounds were created on wild-type and inducible vascular-endothelial-specific mice. deletion in endothelium affected wound healing in following ways. Reepithelialization of wounds in mice was delayed compared with that of wounds in wild-type mice. The degree of angiogenesis of wound granulation tissue was significantly lower in mice than in wild-type mice. Infiltration of F4/80+ macrophages and the expression of MCP-1, IL-1β, and TNF-α were increased in the wound bed of mice compared with wild-type mice. These results confirm that Cdc42 in endothelium is required for angiogenesis and is an essential regulator of key skin wound-healing processes.
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关键词
Cdc42,angiogenesis,inflammation,reepithelialization,skin wound
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