Hubungan Antara Parameter Hematologi saat Perawatan Fase Induksi dengan Kejadian Demam Neutropenia pada Anak Leukemia Limfoblastik Akut

Background :Febrile neutropenia when occurring especially during the inductionphase is a life-threatening condition and requires immediate treatment. The incidenceof febrile neutropenia in Acute Lymphoblastic Leukemia (ALL) induction phase is25% with mortality rate 11% in Dr.Sardjito Hospital. Hematological parametersthought to be contribute to the incidence of febrile neutropenia in children with ALLinduction phase.Objectives : To determine the association between hematologic parameter withseveral variable such as anemia with hemoglobin level (Hb) � 7 g/dL,thrombocytopenia with thrombocyte count � 50000/mm3, lymphopenia withlymphocyte count � 700/mm3, and monocytopenia with monocyte count � 100/mm3related to the event of febrile neutropenia in children with ALL induction phase.Methods : A Case-control study included patients who had undergone and alreadycompleted Indonesian Protocol Acute Lymphoblastic Leukemia (ALL) 2006induction phase, suffered from febrile neutropenia and less than 18 years old.Samples were taken consecutively based on medical records and do matching basedon age, sex, and febrile neutropenia which occurred in first during treatment.Statistics used were chi square and multivariate analysis with multiple logisticregression test.Results : A total of 100 patients were included in the study. Multivariate analysisshows monocytopenia with monocyte count � 100/mm3 was a single risk factorrelated to the event of febrile neutropenia with OR 3,570 (p=0,005