Constant B cell lymphocytosis since early age in a patient with CARD11 mutation: A 20-year follow-up

Tuula Outinen,Jaana Syrjänen,Samuli Rounioja,Janna Saarela,Meri Kaustio,Merja Helminen

Clinical Immunology（2016）

引用 17|浏览24

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摘要

•Lymphocytosis in gain of function (GOF) CARD11 mutation is not always detectable at early age.•Lymphocytosis diminishes towards adulthood.•Lack of NKT cells may play a role in Epstein Barr viremia in GOF CARD11 mutation.•TCRαβ+CD4−CD8− double negative T cells are elevated in GOF CARD11 mutation.

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关键词

Lymphocytosis,EBV,Immunodeficiency

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