Optical coherence tomography of the optic nerve head detects acute changes in intracranial pressure.

•We performed optical coherence tomography (OCT) pre/post cerebrospinal fluid (CSF) drainage in pseudotumor cerebri patients.•We evaluated the immediate response of several anatomical features of the optic nerve head.•The RPE – BM angle became significantly more negative in all patients after CSF drainage.•This preliminary study suggests that acute changes in CSF pressure may be detectable by OCT.