Molecular Imaging and Quantitation of EphA2 Expression in Xenograft Models with 89Zr-DS-8895a.

Ingrid J G Burvenich,Sagun Parakh,Hui K Gan,Fook-Thean Lee,Nancy Guo,Angela Rigopoulos,Sze-Ting Lee,Sylvia Gong,Graeme J O'Keefe,Henri Tochon-Danguy,Masakatsu Kotsuma,Jun Hasegawa,Giorgio Senaldi,Andrew M Scott

Journal of nuclear medicine : official publication, Society of Nuclear Medicine（2016）

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摘要

Molecular imaging of tumor uptake of DS-8895a allows noninvasive measurement of EphA2 expression in tumors in vivo and determination of receptor saturation. (89)Zr-Df-Bz-NCS-DS-8895a is suited for human bioimaging trials on the basis of superior imaging characteristics and will inform DS-8895a dose assessment and patient response evaluation in clinical trials.

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关键词

89Zr,DS-8895a,EphA2,bioimaging,cancer

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