Coenzyme Q biosynthesis in health and disease

Manuel Jesús Acosta,Luis Vazquez Fonseca,Maria Andrea Desbats,Cristina Cerqua, Roberta Zordan,Eva Trevisson,Leonardo Salviati

Biochimica et Biophysica Acta (BBA) - Bioenergetics（2016）

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摘要

Coenzyme Q (CoQ, or ubiquinone) is a remarkable lipid that plays an essential role in mitochondria as an electron shuttle between complexes I and II of the respiratory chain, and complex III. It is also a cofactor of other dehydrogenases, a modulator of the permeability transition pore and an essential antioxidant.

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关键词

Coenzyme Q,Ubiquinone,Coenzyme Q10 deficiency,Mitochondrial disorders,Steroid resistant nephrotic syndrome

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