Coaglio Iv Trial: Randomized, Controlled, Triple-Blind, Multinational Phase Iii Study Of Adjuvant Prophylactic Anticoagulation In Patients With Glioblastoma Who Iv.

TPS2079 Background: Venous thromboembolism (VTE) is a preventable complication in cancer and represents the second most frequent death cause, despite widely available anticoagulants. Further, VTE was proven as paraneoplastic syndrome of tumors, which use the coagulation to support their own aggressiveness. Currently, no guidelines recommend long-term prophylactic anticoagulation, since no data exists to support the use of any officially approved anticoagulant drug. None of the currently available anticoagulants has been adequately tested for its VTE prophylactic power in a cancer patient population. This study aims at providing a rationale for the generation of prophylaxis and treatment guidelines of VTE in cancer patients. This study finally aims to support the long needed completion of paradigm change in oncology since its initial description as Trousseau’s syndrome 150 years ago. Methods: The controlled, triple-blind, multinational phase III study randomizes pts. in a 1:1 fashion to receive either post...