The emergence of low-cost compact mass spectrometry detectors for chromatographic analysis

•New trends in low-cost compact MS chromatographic detectors for chemical analysis.•Recent developments in LC-MS methods using compact MS detectors.•Compact MS instruments at half the cost of conventional spectrometers provide excellent detection sensitivity.•Use of Microsaic 3500 MiD, Advion Compact and Acquity QDa MS detectors across academia and industries.•Use of LC-mini MS for reaction monitoring, biomolecule / high-throughput microplate / impurities / degradation products / trace / PMIs analyzes.