Microwave-assisted synthesis of functionalized spirohydantoins as 3-D privileged fragments for scouting the chemical space

Hugues Prevet,Marion Flipo,Pascal Roussel,Benoit Deprez,Nicolas Willand

Tetrahedron Letters（2016）

引用 26|浏览4

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摘要

•Rapid chemical pathway for the synthesis of new 3D privileged fragments.•Microwave-assisted synthesis of a large set of spirohydantoins.•Selective N-monoalkylation of the hydantoin ring to access functionalized analogs.

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关键词

Fragment library,3-D shape analysis,Spiranic center,Spirohydantoin,Microwave synthesis

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