Prevalence of potential familial hypercholesteremia (FH) in 54,811 statin-treated patients in clinical practice.

•FH is a life threatening disease that is underdiagnosed; its prevalence varies globally.•Prevalence of FH was estimated in 54,811 statin-treated patients in 29 countries.•Across countries, 16.1% of patients had high LDL-C values > 3.6 mmol/L (140 mg/dL).•Prevalence ranged from 6 to 28% for possible FH and was highest in younger persons.•Earlier diagnosis and treatment is needed to reduce CVD risk in FH patients.